Key result
The CRISPR/Cas9 system has remarkable potential for guiding further research into osteoarthritis pathogenesis and may serve as a viable means for treating the disease.
Why the study?
Osteoarthritis progression involves complex genetic and non-genetic factors, and the CRISPR/Cas9 system represents an emerging genome engineering tool with potential for osteoarthritis research and treatment.
The CRISPR/Cas9 system has potential applications in elucidating the pathogenesis of osteoarthritis and may serve as a viable means for treating the disease.
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CRISPR/Cas9 applications in osteoarthritis remain preclinical; leaves open translation to human therapy.
Osteoarthritis is a common degenerative disease of joint cartilage that affects millions of people in the world, especially the elderly. Progression of osteoarthritis is associated with a plethora of genetic and non-genetic factors. The CRISPR/Cas9 system is emerging as a powerful tool for genome engineering and has remarkable potential for guiding further research into osteoarthritis and may be a viable means for treating the disease. This review discusses existing and potential applications of the CRISPR/Cas9 system in osteoarthritis studies and treatments. Firstly, we briefly summarize the current status and mechanism of this technology. Next, we focus on the latest advances in the application of CRISPR/Cas9 system in elucidating the contributions of various factors to the pathogenesis of osteoarthritis as demonstrated through in vitro studies and animal models. Finally, we provide our perspective on the direction and challenges of studying and treating osteoarthritis with CRISPR/Cas9.
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Liang et al. (2025) conducted a review in Osteoarthritis. CRISPR/Cas9 system was evaluated. The CRISPR/Cas9 system has remarkable potential for guiding further research into osteoarthritis pathogenesis and may serve as a viable means for treating the disease.
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