Systemic Lupus Erythematosus and Latent Renal Tubular Dysfunction

Article1 July 1967Systemic Lupus Erythematosus and Latent Renal Tubular DysfunctionW. H. TU, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.W. H. TU, M.D., F.A.C.P.Search for more papers by this author, MARTIN A. SHEARN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-100 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRenal tubular acidosis (1), an impairment of renal acid excretion out of proportion to reduction of glomerular filtration rate, has been described in a variety of clinical settings. Its characteristic clinical manifestations are hyperchloremic acidosis, an inability to excrete a highly acid urine, and impaired renal concentrating ability. It may be associated, in the primary form, with renal calculi, nephrocalcinosis, osteomalacia, and potassium depletion (2). Subclinical cases—either asymptomatic or lacking the laboratory findings of the overt cases of renal tubular acidosis—have been uncovered by an acid-loading test designed to detect acid excretion inappropriate to the induced metabolic acidosis (3, 4)....References1. ELKINTON JR: Renal acidosis (editorial). Amer. J. Med. 28: 165, 1960. CrossrefMedlineGoogle Scholar2. MILNE MD: Renal tubular dysfunction, in Diseases of the Kidney, edited by STRAUSS, M. B., WELT, L. G. Little, Brown and Co., Boston, 1963, p. 786. Google Scholar3. ELKINTONHUTHWEBSTERMCCANCE JREJGDRA: The renal excretion of hydrogen ion in renal tubular acidosis. I. Quantitative assessment of the response to ammonium chloride as an acid load. Amer. J. Med. 29: 554, 1960. CrossrefMedlineGoogle Scholar4. WRONGDAVIES OHE: The excretion of acid in renal disease. Quart. J. Med. 28: 259, 1959. MedlineGoogle Scholar5. KAHNMERRITTWOHLORLOFF MADMJJ: Renal concentrating defect in Sjögren's syndrome. Ann. Intern. Med. 56: 883, 1962. 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Author, Article, and Disclosure InformationAffiliations: Oakland, CaliforniaFrom the Department of Medicine, The Permanente Medical Group, Kaiser Foundation Hospital, Oakland, Calif.This study was supported by research grant 117256, Kaiser Foundation, Oakland, Calif., and by a grant from The Arthritis Foundation, Northern California Chapter, San Francisco, Calif.Requests for reprints should be addressed to W. H. Tu, M.D., Kaiser Foundation Hospitals, 280 W. MacArthur Blvd., Oakland, Calif. 94611. 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CHAIMOWITZ, M.D., Y. NAVEH, M.D., A. STEIN, M.D., A. M. NAHIR, M.D., A. BARZILAI, M.D., D. ERLIK, M.D.RENAL TUBULAR ACIDOSIS AND HYPERGAMMAGLOBULINAEMIC PURPURA IN A 10 YEAR OLD GIRL WITH ROENTGENOGRAPHIC SIGNS SUGGESTING MEDULLARY SPONGE KIDNEYSecondary proximal tubular acidosisRenal Tubular Acidosis in CirrhosisRenal Tubular Acidosis, Glomerulonephritis and Immunologic Factors in Sjogren's SyndromeDefective Urinary Acidification in Wilson's DiseaseMILFORD FULOP, M.D., IRMIN STERNLIEB, M.D., I. HERBERT SCHEINBERG, M.D.Latent renal tubular acidosis in Sjogren's syndrome. 1 July 1967Volume 67, Issue 1Page: 100-109KeywordsArthritisExcretionGlomerular filtration rateHospital medicineKidney stonesLupus erythematosusPotassiumResearch grantsResearch laboratoriesUrine Issue Published: 1 July 1967 PDF downloadLoading ...