Why the study?
Does hyperlipidemia disrupt cerebrovascular reflexes and worsen ischemic perfusion defects in the absence of overt atherosclerosis?
Population
Apolipoprotein E knockout mice before the development of flow-limiting atherosclerotic stenoses
Comparison
Hyperlipidemia vs Wild type mice
Design
Preclinical
Authors
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Hyperlipidemia may impair cerebrovascular autoregulation and collateral perfusion in stroke; leaves open translation to humans without atherosclerosis.
Does hyperlipidemia disrupt cerebrovascular reflexes and worsen ischemic perfusion defects in the absence of overt atherosclerosis?
Hyperlipidemia disrupts cerebral blood flow regulation and diminishes collateral perfusion during acute stroke even before the development of flow-limiting atherosclerosis.
Ayata et al. (2013) studied this question.
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