Why the study?
Is long-term plasma exchange safe and feasible during pregnancy in women with homozygous familial hypercholesterolemia?
Population
2 pregnant women with homozygous familial hypercholesterolemia (HFH) undergoing a total of 5 pregnancies
Design
Case_series
Follow-up
throughout pregnancy
Authors
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Intensified plasma exchange may enable HoFH pregnancies with monitoring; leaves open safety and generalizability in larger studies.
Is long-term plasma exchange safe and feasible during pregnancy in women with homozygous familial hypercholesterolemia?
Pregnancy in women with homozygous familial hypercholesterolemia treated with plasma exchange is feasible but requires increased exchange frequency and close hemodynamic monitoring, particularly in the presence of valvular lesions like aortic stenosis.
Beigel et al. (1998) studied this question.
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