This case report is the first to evaluate mucin gene expression (MUC1, MUC2, MUC5AC) in an unusual, incompletely resectable cardiac myxoma.
Mucin profiling in rare cardiac myxoma is hypothesis-generating; extends histopathology but should not change practice.
Myxoma is the most common benign neoplasm of the heart. This work is the first to present an unusual left atrium and mitral valve cardiac myxoma which cannot be completely resected. This cardiac myxoma was also associated with abundant mucopolysaccharidic matrix, including mucin. Mucin gene expression is cell- and tissue-specific, with variations during cell differentiation and inflammation, and is altered during carcinogenesis. The expression of mucin genes in cardiac myxoma has never been elucidated previously. Detailed immunohistochemical analysis of MUC1, MUC2 and MUC5AC has been performed in this left atrium and mitral valve myxoma. Notably, the expressions of mucins in cardiac myxoma must be further evaluated.
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Chu et al. (2004) studied this question.
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