September 30, 2016PLoS ONEOpen Access

Association of Apolipoprotein C3 Genetic Polymorphisms with the Risk of Ischemic Stroke in the Northern Chinese Han Population

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Why the study?

Do APOC3 genetic polymorphisms (rs2854116, rs2854117, rs4520, rs5128) increase the risk of ischemic stroke in the northern Chinese Han population?

Population

1,778 adults aged 40 to 80 years from the northern Chinese Han population, comprising 895 patients with a…

Comparison

Presence of apolipoprotein C3 single nucleotide… vs Wild-type/reference genotypes and healthy…

Design

Case-control

Authors

YWYanzhe WangHenan University of Science and Technology XYXiaoyu YinVerizon (United States)LLLei LiGuiyang Medical University

Discussion

Member takes

Implication

Should not yet change stroke risk assessment; hypothesis-generating for gender-specific APOC3 effects in northern Chinese Han females and needs replication.

Structured PICO

Do APOC3 genetic polymorphisms (rs2854116, rs2854117, rs4520, rs5128) increase the risk of ischemic stroke in the northern Chinese Han population?

Population

1,778 adults aged 40 to 80 years from the northern Chinese Han population (Liaoning province), comprising 895 patients with a first diagnosis of acute ischemic stroke and 883 healthy, age- and sex-matched controls. Exclusions included transient ischemic attack, cardioembolism, cerebral trauma, cerebrovascular malformations, coagulation disorders, autoimmune diseases, tumors, chronic infectious diseases, renal or liver diseases, hematopathy, occlusive arterial disease, or phlebothrombosis.

Intervention

Presence of apolipoprotein C3 (APOC3) single nucleotide polymorphisms (SNPs) rs2854116, rs2854117, rs4520, and rs5128.

Comparator

Wild-type/reference genotypes (e.g., GG genotype for rs5128, TT genotype for rs4520) and healthy control subjects without stroke or neurological diseases.

Outcome

Risk of ischemic stroke (susceptibility based on genotype distributions and allele frequencies).hard clinical

APOC3 genetic polymorphisms (rs5128 and rs4520) are independently associated with an increased risk of ischemic stroke specifically in northern Chinese Han females, suggesting a gender-specific genetic susceptibility.

Limitations

Small sample size
Lack of reproducibility evaluation in a second cohort
Limited to the northern Chinese Han population, unclear if applicable to other ethnicities
Retrospective case-control design cannot confirm a cause-effect relationship
Lack of measurements of APOC3 mRNA and plasma APOC3 concentrations
Did not evaluate multiple other genes and environmental factors related to ischemic stroke

Cite This Study

Wang et al. (2016) studied this question.

synapsesocial.com/papers/6a85bc0a581d4f62e2d5b8fe https://doi.org/10.1371/journal.pone.0163910

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Implication

Should not yet change stroke risk assessment; hypothesis-generating for gender-specific APOC3 effects in northern Chinese Han females and needs replication.

Association of Apolipoprotein C3 Genetic Polymorphisms with the Risk of Ischemic Stroke in the Northern Chinese Han Population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Association of Apolipoprotein C3 Genetic Polymorphisms with the Risk of Ischemic Stroke in the Northern Chinese Han Population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider