What question did this study set out to answer?

To determine whether staining for dipeptidyl aminopeptidase IV (DAP IV) activity in cytologic and imprint specimens can reliably distinguish benign from malignant thyroid diseases.

September 1, 1991American Journal of Clinical Pathology

Dipeptidyl Aminopeptidase IV Staining of Cytologic Preparations to Distinguish Benign from Malignant Thyroid Diseases

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Authors

YAYatsuki AratakeKyushu University of Health and Welfare TKTomio KotaniUniversity of Miyazaki KTKazuo TamuraKindai University

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Implication

Diagnostic evaluation demonstrates strong dipeptidyl aminopeptidase IV staining in malignant thyroid tumors, indicating high utility for distinguishing benign from malignant lesions.

Key Points

To determine whether staining for dipeptidyl aminopeptidase IV (DAP IV) activity in cytologic and imprint specimens can reliably distinguish benign from malignant thyroid diseases.
Stained aspiration biopsy specimens or surgical imprint preparations for DAP IV activity across 55 patients with histologically proven thyroid diseases.
Sample included 9 papillary carcinomas, 5 follicular carcinomas, 11 follicular adenomas, 13 adenomatous goiters, 8 Hashimoto's thyroiditis cases, and 9 other benign conditions.
Scored samples using a composite DAP IV system evaluating the percentage of positive cells and staining intensity.
Most tumor cells, follicular lumina, and intranuclear inclusions were strongly positive for DAP IV in 100% of papillary carcinoma (9/9) and follicular carcinoma (5/5) specimens.
Follicular adenomas and adenomatous goiters demonstrated DAP IV labeling in only a few epithelial cells, though some Hürthle cells in Hashimoto's thyroiditis were positive.
DAP IV scoring yielded extremely low scores in all benign tissues except for a single follicular adenoma specimen.

Cite This Study

Aratake et al. (1991) studied this question.

synapsesocial.com/papers/6a85bdc1d06b31cc19d0da54 https://doi.org/10.1093/ajcp/96.3.306

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Implication

Diagnostic evaluation demonstrates strong dipeptidyl aminopeptidase IV staining in malignant thyroid tumors, indicating high utility for distinguishing benign from malignant lesions.

Dipeptidyl Aminopeptidase IV Staining of Cytologic Preparations to Distinguish Benign from Malignant Thyroid Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Dipeptidyl Aminopeptidase IV Staining of Cytologic Preparations to Distinguish Benign from Malignant Thyroid Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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