Key result
In acute STEMI patients undergoing delayed PCI, female gender was associated with a significantly higher risk of major adverse cardiac events at 30 days (OR 10.91).
Why the study?
Certain factors may increase the risk of MACE after delaying PCI, prompting the authors to determine risk factors for MACE outcomes in acute STEMI patients undergoing PCI during their index admission.
Observational (n=91)
No
Odds Ratio: 10.91 (95% CI 1.35–87.8)
p-value: p=0.025
In STEMI patients undergoing delayed PCI during index admission, female gender, lower systolic blood pressure, higher heart rate, and history of CAD are significant predictors of MACE at 30 days and 6 months.
These factors may prompt closer post-PCI monitoring in STEMI; leaves open need for prospective validation before guiding practice.
Introduction: Patients with ST-segment elevation myocardial infarction (STEMI) often undergo percutaneous coronary intervention (PCI) procedures during their index hospitalisation. However, some factors may increase the risk of major adverse cardiac event (MACE) outcomes after delaying PCI. We aimed to determine the risk factors for MACE outcomes in acute STEMI patients who had PCI during their index admission. Methods: In this retrospective single-center study, the medical records of STEMI patients who had PCI during their index hospitalisation in our facility were retrieved. At 30 days and six months post-PCI, demographic characteristics, clinical presentation, coronary risk factors, and the rate of MACE outcome were recorded and analysed. Results: This study included 91 STEMI patients. At 30 days and six months post-PCI, the rate of MACE was 10.5% and 8.0% respectively. At 30 days post-PCI, gender (p = 0.025), systolic blood pressure (p = 0.005) and heart rate (p = 0.003) were all associated with MACE outcomes. At six months, systolic blood pressure (p = 0.017), heart rate (p = 0.003), and previous coronary artery disease (CAD) (p = 0.014) were all associated with MACE. Conclusion: In acute STEMI patients, female gender, systolic blood pressure, heart rate, and a history of CAD are the risk factors for MACE outcomes after the PCI during the index admission. However, this is only single center study with short follow up period. Therefore, multi centers study and longer follow up period could provide better understanding on the factors associated with delayed PCI.
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Mohammed et al. (2023) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=91). Female gender vs. Male gender was evaluated on Major adverse cardiac events (MACE) at 30 days (OR 10.91, 95% CI 1.35-87.80, p=0.025). In acute STEMI patients undergoing delayed PCI, female gender was associated with a significantly higher risk of major adverse cardiac events at 30 days (OR 10.91).
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