Key result
Diastolic left ventricular mechanical dyssynchrony parameters (PSD >55.5° and HBW >174.5°) derived from GSPECT predicted MACE in post-MI patients with 75% sensitivity and 80.8-83.3% specificity.
Why the study?
The study aimed to evaluate the prognostic value of diastolic left ventricular mechanical dyssynchrony measured by GSPECT MPI in post-MI patients.
Does diastolic left ventricular mechanical dyssynchrony measured by GSPECT MPI predict MACE in post-myocardial infarction patients?
Cohort (n=106)
Does diastolic left ventricular mechanical dyssynchrony measured by GSPECT MPI predict MACE in post-myocardial infarction patients?
Diastolic left ventricular mechanical dyssynchrony parameters (PSD and HBW) derived from GSPECT are significant prognostic factors for predicting MACE in post-MI patients.
Diastolic LVMD by GSPECT may refine post-MI risk stratification; hypothesis-generating and requires validation before clinical adoption.
Objective This study is aimed to assess the prognostic value of diastolic left ventricular mechanical dyssynchrony (LVMD) measured by gated-single photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in post-myocardial infarction (MI). Subjects and Methods The study was conducted on 106 post-MI from January 2015 to January 2019. First, the indices of diastolic LVMD phase standard deviation (PSD) and histogram bandwidth (HBW) of post-MI were measured using the Cardiac Emory Toolbox. Subsequently, the post-MI patients were followed up, and the primary endpoint was major adverse cardiac events (MACEs). Finally, the prognostic value of dyssynchrony parameters for MACE was analyzed by the receiver-operating characteristics curve and survival analyses. Results With the cut-off values of 55.5 degrees of PSD, the sensitivity and specificity in prediction of MACE were 75% and 80.8%, with the cut-off values of 174.5 degrees of HBW, the sensitivity and specificity were 75% and 83.3% respectively. There was a significant difference of time to MACE between groups of PSD less than 55.5 degrees and more than 55.5 degrees. PSD, HBW, and left ventricle ejection fraction (LVEF) assessed on GSPECT were significant factors in the prediction of MACE. Conclusion Diastolic LVMD parameters of PSD and HBW derived from GSPECT are significant prognostic factors in predicting MACE in post-MI patients.
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Hà et al. (2023) conducted a cohort in post-myocardial infarction (n=106). Diastolic left ventricular mechanical dyssynchrony (LVMD) by GSPECT was evaluated on major adverse cardiac events (MACEs). Diastolic left ventricular mechanical dyssynchrony parameters (PSD >55.5° and HBW >174.5°) derived from GSPECT predicted MACE in post-MI patients with 75% sensitivity and 80.8-83.3% specificity.
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