Resting aortic stiffness was inversely associated with gray matter volume in patients with type 2 diabetes (standardized β = -0.47), whereas resting excess pressure was inversely associated with gray matter volume in healthy individuals.
Cross-Sectional (n=74)
Single-blind (MRI examiners)
No
Does Type 2 Diabetes Mellitus alter the association between central hemodynamics and structural brain changes compared to healthy individuals?
Central vascular mechanisms underlying structural brain changes may differ between healthy individuals and those with T2DM, with brain atrophy associated with resting aortic stiffness in T2DM and resting excess pressure in healthy individuals.
Effect estimate: standardized β = -0.47
p-value: p=0.036
BACKGROUND: Central hemodynamics help to maintain appropriate cerebral and other end-organ perfusion, and may be altered with ageing and type 2 diabetes mellitus (T2DM). We aimed to determine the associations between central hemodynamics and brain structure at rest and during exercise in people with and without T2DM. METHODS: In a sample of people with T2DM and healthy controls, resting and exercise measures of aortic reservoir characteristics (including excess pressure integral P(excess)) and other central hemodynamics (including augmentation index AIx and aortic pulse wave velocity aPWV) were recorded. Brain volumes (including gray matter volume GMV and white matter lesions WML) were derived from magnetic resonance imaging (MRI) scans. Multivariable linear regression was used to study the associations of hemodynamic variables with brain structure in the two groups adjusting for age, sex, daytime systolic BP (SBP) and heart rate. RESULTS: There were 37 T2DM (63 ± 9 years; 47% male) and 37 healthy individuals (52 ± 8 years; 51% male). In T2DM, resting aPWV was inversely associated with GMV (standardized β = -0.47, p = 0.036). In healthy participants, resting P(excess) was inversely associated with GMV (β = -0.23, p = 0.043) and AIx was associated with WML volume (β = 0.52, p = 0.021). There were no associations between exercise hemodynamics and brain volumes in either group. CONCLUSIONS: Brain atrophy is associated with resting aortic stiffness in T2DM, and resting P(excess) in healthy individuals. Central vascular mechanisms underlying structural brain changes may differ between healthy individuals and T2DM.
Climie et al. (2014) conducted a cross-sectional in Type 2 diabetes mellitus (n=74). Central hemodynamics (aortic reservoir characteristics and aortic stiffness) vs. Healthy controls was evaluated on Association between resting aortic pulse wave velocity (aPWV) and gray matter volume in patients with type 2 diabetes (standardized β = -0.47, p=0.036). Resting aortic stiffness was inversely associated with gray matter volume in patients with type 2 diabetes (standardized β = -0.47), whereas resting excess pressure was inversely associated with gray matter volume in healthy individuals.