Key result
Baseline anemia is a strong independent predictor of major adverse cardiac outcomes, major bleeding, and mortality in patients undergoing percutaneous coronary intervention.
Why the study?
Does baseline anemia predict worse outcomes in patients undergoing PCI?
Does baseline anemia predict worse outcomes in patients undergoing PCI?
Baseline anemia is strongly associated with worse outcomes, including MACE, major bleeding, and mortality, after PCI, though current evidence remains hypothesis-generating.
Substantial evidence from epidemiological studies suggests strong association between baseline anemia and worse outcomes following percutaneous coronary intervention (PCI) for both stable coronary artery disease (CAD) and acute coronary syndromes (ACS) (1-3). The existing data, almost exclusively from prospective analysis of clinical cohorts or retrospective post-hoc analysis of data from large randomized clinical trials designed to investigate other specific endpoints, point to anemia as a strong independent predictor of major adverse cardiac outcomes (MACE), major bleeding and mortality in patients undergoing PCI (4-6). Some of the published studies have utilized rigorous statistical methods to adjust for all known and measurable variables that can interact with anemia, nevertheless the associations inferred from these studies, while providing valuable insights, remain hypothesis generating.
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Galougahi et al. (2016) conducted an editorial in Coronary artery disease (CAD) and acute coronary syndromes (ACS) undergoing PCI. Baseline anemia was evaluated on Major adverse cardiac outcomes (MACE), major bleeding, and mortality. Baseline anemia is a strong independent predictor of major adverse cardiac outcomes, major bleeding, and mortality in patients undergoing percutaneous coronary intervention.
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