Key result
ANGPT4 promotes tumor proliferation, survival, and angiogenesis by affecting the TIE2, ERK1/2, and PI3K/AKT signaling pathways, highlighting its potential as a prognostic biomarker and therapeutic target.
Why the study?
To review the role of ANGPT4 in tumourigenesis, its carcinogenic function, and the development of ANGPT4 inhibitors.
This review highlights the role of ANGPT4 in promoting tumor angiogenesis and its potential as a diagnostic biomarker and therapeutic target in oncology.
As one of the factors regulating tumour angiogenesis, angiopoietin-4 (ANGPT4), which plays an important role in promoting tumour proliferation, survival, expansion and angiogenesis, is highly expressed in some tumours, such as lung adenocarcinoma, glioblastoma and ovarian cancer. This may be related to the fact that ANGPT4 affects the blood vessels and lymphatic system of the tumour. Specifically, ANGPT4 could play an effective role in promoting cancer by affecting the tyrosine kinase receptor TIE2, ERK1/2 and PI3K/AKT signalling pathways. Therefore, ANGPT4 may be an important biomarker for the occurrence and development of cancer and poor prognosis. In addition, the inhibition of ANGPT4 may be a useful cancer treatment. This paper reviews the latest preclinical research on ANGPT4, emphasizes its role in tumourigenesis and broadens our understanding of the carcinogenic function of ANGPT4 and the development of ANGPT4 inhibitors. This is the latest version of the revised version of the previous article.
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Zhou et al. (2024) conducted a review in Cancer. ANGPT4 was evaluated. ANGPT4 promotes tumor proliferation, survival, and angiogenesis by affecting the TIE2, ERK1/2, and PI3K/AKT signaling pathways, highlighting its potential as a prognostic biomarker and therapeutic target.
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