Key result
Proinflammatory cytokines and mediators originating from adipose tissue actively promote atherosclerosis and atherothrombosis.
This review summarizes the role of adipose tissue-derived proinflammatory mediators in promoting atherosclerosis and atherothrombosis.
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Should not yet change clinical practice; leaves open whether targeting adipose inflammation improves cardiovascular outcomes.
Extensive research of recent decades has revealed manifold metabolic functions of adipose tissue, beyond its purpose as a simple storage organ for fatty acids. Consequently, proinflammatory mediators have been identified that actively promote atherosclerosis. This review therefore highlights the complex interactions between selected cytokines and mediators originating from adipose tissue and atherothrombosis.
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Rohla et al. (2014) conducted a review in Atherosclerosis. Adipose tissue-derived cytokines and mediators was evaluated. Proinflammatory cytokines and mediators originating from adipose tissue actively promote atherosclerosis and atherothrombosis.
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