January 19: Radium, 542 mc, intralaryngeally, for three and one-half minutes ; no change in the size or number of the growths.February 9 : Radium, 1,065 mc, intralaryngeally, for three minutes.Radium apparently had no effect on the growths in the larynx.March 2 : Excision of papillomas through mouth.March 13: Radium, 1,118 mg., direct to throat externally-three areas- twenty minutes each.May 27: Radium, 926 mg., in lead box on 1 inch (2.54 cm.) gauze applied to larynx-two areas-one-half hour each.June, 15: Complete aphonia; papillomas have recurred; again excised.Radium, 1 gm., externally, in front and on each side of larynx for thirty minutes; lead 3 mm. in thickness interposed; distance one-half inch (12.7 mm.); total exposure one and one-half hours.July 10: Radium, 584 mg., in lead tube with three-fourths inch (19.05 mm.) gauze applied to larynx-three areas-twenty minutes each.August 7: Radium, 150 mg., applied to neck at three-fourths inch (19.05 mm.) distance for one hour.August 28: Radium, 150 mg., three-fourths inch (19.05 mm.) distance, applied to larynx-three areas-one-half hour each.September 25: Radium, 150 mg., at three-fourths inch (19.05 mm.), applied to larynx for one-half hour.October 31: Radium, 1,535 mg., at one-eighth inch (3.17 mm.), applied to three areas on neck for fifteen minutes.November 20 : Radium, 700 mg., in a tube with open end, placed directly on papillomas for five minutes.A profuse purulent bloody discharge is coughed out of the trachéal tube.Larynx contains perhaps more papillomas than on admission.Jan. 23, 1919 : Papillomas in trachea both above and below the trachéal tube.These were removed under local anesthesia.unchanged ; no local treatment.October 25 : Larynx examined under general anesthesia ; growths had entirely disappeared, but there was a partial paralysis of the left vocal cord.
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Samuel J. Crowe (1922) studied this question.
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