Why the study?
Does ephedrine prevent recurrence of ventricular arrhythmia in a patient with Stokes-Adams syndrome and underlying bradycardia?
Does ephedrine prevent recurrence of ventricular arrhythmia in a patient with Stokes-Adams syndrome and underlying bradycardia?
Ephedrine may be of value in treating Stokes-Adams attacks due to ventricular arrhythmia in patients with an underlying bradycardia.
Answers are grounded in this paper and cite their sources.
May support ephedrine in quinidine-refractory ventricular arrhythmia with bradycardia; leaves open confirmation in prospective Stokes-Adams trials.
An unusual case of ventricular arrhythmia is reported with electrocardiograms showing complete attacks of ventricular tachycardia, ventricular flutter and ventricular fibrillation. The etiologyis unknown. Large doses of quinidine, to the point of toxicity, seemed to halt the arrhythmia but did not prevent its recurrence. Ephedrine was given with resulting immediate improvement and no recurrence of the arrhythmia. It is suggested that ephedrine may be of value in treating Stokes-Adams attacks due to ventricular arrhythmia in which there is no heart block but an underlying bradycardia.
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Donald A. Dupler (1953) studied this question.
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