April 1, 1981The Journal of Immunology

In vivo interaction of bacterial lipopolysaccharide (LPS) with rabbit platelets: modulation by C3 and high density lipoproteins.

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Population

Rabbits

Design

Preclinical

Follow-up

Up to 20 hours

Authors

JMJohn C. MathisonScripps Research Institute RURichard J. UlevitchScripps Research Institute

Discussion

Member takes

Implication

LPS effects on coagulation/hemodynamics may occur without platelet binding; leaves open primary cellular targets in endotoxemia models.

Structured PICO

Population

Rabbits (including a group depleted of C3 and terminal complement components by prior injection of cobra venom factor)

Intervention

Intravenous injection of 250 μg of Salmonella minnesota R595 LPS (with 125I-LPS tracer) or LD-LPS

Outcome

Kinetics and specificity of binding of LPS to blood elementssurrogate

Binding of LPS to platelets does not appear to play a major role in the initiation of hypotension and disseminated intravascular coagulation after LPS injection.

Cite This Study

Mathison et al. (1981) studied this question.

synapsesocial.com/papers/6a85c5a737bcb8373dadbbab https://doi.org/10.4049/jimmunol.126.4.1575

View Full Paper

Ask AI

Bookmark

In vivo interaction of bacterial lipopolysaccharide (LPS) with rabbit platelets: modulation by C3 and high density lipoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In vivo interaction of bacterial lipopolysaccharide (LPS) with rabbit platelets: modulation by C3 and high density lipoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider