Key result
Azithromycin had no effect on QT interval in children.
Cohort
Does not support routine QT monitoring with azithromycin in children; leaves open need for randomized confirmation.
Macrolides are a group of antimicrobial drugs used widely, being well known for their adverse cardiac effects. Erythromycin and clarithromycin are most commonly associated with these conditions. In recent years, azithromycin (AZM) has been assessed because of its possible relation to arrhythmias (mainly QT interval prolongation) and risk of cardiovascular death.1 The pharmacodynamics of these effects is complex and the occurrence of cardiovascular death is unpredictable.2 However, all published manuscripts on the cardiac effects of AZM to date are cases in adults or …
No takes yet. Share an insight, caveat, or question.
Maciá et al. (2016) reported a cohort. Azithromycin was evaluated on QT interval. Azithromycin had no effect on QT interval in children.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: