Investigating the Effect of Foot Reflexology Massage on Post-electroconvulsive Therapy Headache

Introduction: High intensity interval training can promote PGC-1 and TFAM key regulator of mitochondrial biogenesis. Then the purpose of this investigation is to examine the effect of high intensity interval training whit supplementation of sodium citrate on PGC-1 and TFAM expression in soleus muscle of Wistar rats. Methods: 24 Wistar rats were randomly divided into 3 groups of control, training and training with sodium citrate supplementation. Both training and training with sodium citrate supplementation groups performed high intensity interval training for 8 weeks, five days a week, with the intensity of 50% to 90% maximum running speed on rodent treadmill. The training with supplement group were treated with a dose (15 mmol/L) of sodium citrate by drinking water per day for 8 weeks. Statistical evaluations of the experiments were investigated by applying One-Way ANOVA and Tukey's post hoc analysis with a statistical level of P < 0.05. Cohen's d also was calculated to compare groups. Results: Findings indicated significant differences in PGC-1 and TFAM protein level in both training and training with supplement groups compared to control group (P = 0.001). Results about sodium citrate supplementation also showed significant differences in training with supplementation group compared to training group (P = 0.005). Conclusions: It seems sodium citrate supplementation can induce expression of PGC-1 and TFAM and increases level of PGC-1 and TFAM proteins.