Effects of L-arginine-derived nitric oxide synthesis on neuronal activity in nucleus tractus solitarius

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Population

Fischer-344 rats (in vivo anesthetized and in vitro brain slices)

Comparison

NG-nitro-L-arginine methyl ester 10 mg/kg iv or… vs Baseline neuronal activity

Design

Preclinical

Authors

Discussion

Nitric oxide modulates NTS neuron activity in rodents; leaves open its role in human central autonomic cardiovascular control.

Population

Fischer-344 rats (in vivo anesthetized and in vitro brain slices)

Intervention

NG-nitro-L-arginine methyl ester (L-NAME) 10 mg/kg iv (in vivo) or 1 mM (in vitro), with reversal by L-arginine or nitroglycerin

Comparator

Baseline neuronal activity

Outcome

Single unit neuronal discharge rate in medial nucleus tractus solitarius (NTS) neuronssurrogate

L-arginine-derived nitric oxide influences the spontaneous discharge rate of NTS neurons, suggesting a role in central autonomic control.

Ma et al. (1995) studied this question.

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