Key result
In healthy young adults, body mass index was positively associated with aortic wall area (β = 0.01) and aortic wall thickness, while blood pressure was associated with increased aortic pulse wave velocity.
Cross-Sectional (n=124)
No
In asymptomatic young adults, cardiovascular risk factors such as age, sex, BMI, and blood pressure are already associated with MRI-derived early signs of subclinical atherosclerosis and aortic stiffness.
More detailed evaluation of atherosclerosis and its key determinants in young individuals is warranted to improve knowledge on the pathophysiology of its development and progression. This study evaluated associations of magnetic resonance imaging (MRI)-derived aortic wall area, wall thickness, and pulse wave velocity (PWV) with cardiovascular risk factors in asymptomatic, young adults. In 124 adults (age: 25–35 years) from the general population-based Atherosclerosis Monitoring and Biomarker Measurements in the Young study, demography, anthropometry, and blood samples were collected. The studied MRI-parameters were measured using a 3.0T MRI system. Relations between cardiovascular risk factors and aortic characteristics were assessed using multivariable linear regression analyses. Mean age was 31.8 years, 47.6% was male. Aortic wall area was positively associated with age [ β = 0.01, (95% confidence interval (CI) 2.00 × 10 −3 , 0.02), p = 0.01] and BMI [ β = 0.01, (0.01, 0.02), p = 0.003] and negatively associated with sex (reference: men) [ β = −0.06, (−0.11, −0.01), p = 0.02]. Natural logarithm transformed (ln) aortic wall thickness was positively associated with BMI [ β = 0.01, (1.00 × 10 −3 , 0.02), p = 0.02]. Ln aortic PWV was positively associated with 10 mmHg increment of SBP [ β = 0.06, (0.03, 0.09), p < 0.001] and DBP [ β = 0.06, (0.02, 0.09), p = 0.006]. No relations were observed for smoking and lipids. Already in early adulthood, aortic wall geometry and stiffness vary by age, sex, BMI, and blood pressure.
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Eikendal et al. (2017) conducted a cross-sectional in Healthy, asymptomatic young adults (n=124). Body mass index (BMI) was evaluated on Aortic wall area (β = 0.01, 95% CI 0.01, 0.02, p=0.003). In healthy young adults, body mass index was positively associated with aortic wall area (β = 0.01) and aortic wall thickness, while blood pressure was associated with increased aortic pulse wave velocity.
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