Effects of 1-year exercise in patients with atrial fibrillation: study protocol for the Norwegian Exercise in Atrial Fibrillation (NEXAF) randomised controlled trial
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Why the study?
Does a 12-month combined supervised and eHealth-based exercise intervention reduce atrial fibrillation burden and improve quality of life in previously inactive patients with paroxysmal or persistent atrial fibrillation?
Population
Patients aged 18-80 years with paroxysmal or persistent AF who were previously inactive
Comparison
Combined supervised and eHealth-based exercise intervention vs usual care
Design
Multicentre two-arm randomised controlled trial
Follow-up
12 months
Authors
Discussion
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Implication
Exercise-related AF was associated with lower stroke risk; leaves open whether exercise modifies thromboembolic outcomes.
Structured PICO
Does a 12-month combined supervised and eHealth-based exercise intervention reduce atrial fibrillation burden and improve quality of life in previously inactive patients with paroxysmal or persistent atrial fibrillation?
P
Population
Previously inactive patients 18-80 years with a confirmed diagnosis of paroxysmal or persistent atrial fibrillation managed with a rhythm control strategy, in sinus rhythm at baseline.
I
Intervention
Combined supervised and eHealth-based exercise intervention for 12 months (aiming for 150-300 min of moderate-intensity or 75-150 min of vigorous-intensity activity per week), including initial supervised sessions, a smartwatch, and an eHealth platform for monitoring and support.
C
Comparator
Usual care (standard management according to usual practice, including guideline-directed medical therapy and oral information about general physical activity recommendations at enrolment, with no further supervision).
O
Outcome
Total time in atrial fibrillation measured by insertable cardiac monitors, and disease-specific quality of life measured by the overall sum score of the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire at 12 months.surrogate
The NEXAF trial protocol outlines a randomized controlled trial to evaluate whether a 12-month structured exercise intervention reduces atrial fibrillation burden and improves quality of life in previously inactive patients.
Cite This Study
Nes et al. (2025) studied this question.
Topics
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