Ingestion of certain unsubstituted sulphonamides causes an increased excretion of sodium, potassium, and bicarbonate ions. The effects are probably due to reduction of the quantity of hydrogen ions available for secretion by the renal tubules, with consequent impairment of the Na+- H+ exchange postulated by Pitts and Alexander as being responsible for the tubular reabsorption of bicarbonate ( 1 ).
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Hanley et al. (1956) studied this question.