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That there is a reduction of the CO2 content of the serum of patients receiving sulfanilamide was pointed out by Southworth (1). This finding has been regularly encountered by other observers. Usually hyperpnea of varying degrees is present. The development of severe acidosis is, however, very rare. That the urine becomes strongly al- kaline at the same time was pointed out by Bas- man and Perley (2).
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Beckman et al. (1940) studied this question.
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