Why the study?
Does a high-salt diet affect renal hemodynamics and proteinuria in hypertensive patients compared to a low-salt diet?
Population
22 hypertensive patients (9 white, 13 black) with normal serum creatinine
Comparison
High-salt diet (200 mEq Na+/d) for 2 weeks vs Low-salt diet for 2 weeks
Design
RCT, Randomized to receive either 2 weeks of a low-salt or high-salt diet…
Follow-up
2 weeks per diet phase
Authors
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High-salt diets may worsen glomerular hyperfiltration and proteinuria in salt-sensitive hypertension; extends salt-restriction evidence to renal hemodynamics.
Does a high-salt diet affect renal hemodynamics and proteinuria in hypertensive patients compared to a low-salt diet?
In salt-sensitive hypertensive patients, a high-salt diet induces potentially adverse increases in glomerular filtration rate and proteinuria, which correlate with increases in systolic blood pressure.
Dengel et al. (1995) studied this question.
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