June 1, 2002HypertensionOpen Access

KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF

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Why the study?

Does KDR or Flt-1 mediate the hypotensive effect of VEGF in conscious rats?

Population

In vitro vascular endothelial cells and in vivo conscious rats

Comparison

Intravenous injection of KDR-selective mutant… vs Compared against each other and placenta growth…

Design

Preclinical

Authors

BLBing LiSecond Military Medical University AOAnnie OgasawaraUniversity of Notre Dame RYRenhui YangWuhan Institute of Technology

Discussion

Member takes

Implication

KDR-selective VEGF mutants may lessen hypotension in rat ischemia models; leaves open human translation pending clinical studies.

Structured PICO

Does KDR or Flt-1 mediate the hypotensive effect of VEGF in conscious rats?

Population

In vitro vascular endothelial cells and in vivo conscious rats

Intervention

Intravenous injection of KDR-selective mutant, Flt-selective mutant, or VEGF

Comparator

Compared against each other and placenta growth factor

Outcome

Mean arterial pressure (hypotension) and vasorelaxationsurrogate

KDR is the predominant receptor mediating the vasodilation and hypotensive effect of VEGF, suggesting KDR-selective mutants could be an alternative treatment for ischemic diseases with less hypotension.

Cite This Study

Li et al. (2002) studied this question.

synapsesocial.com/papers/6a85cd49b391086d4cbbc6b0 https://doi.org/10.1161/01.hyp.0000018588.56950.7a

View Full Paper

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KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF

Discussion

Member takes

Implication

Structured PICO

Cite This Study

KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider