New Observations in Generalized Cytomegalic-Inclusion Disease of the Newborn

THE patient discussed below was considered to be a normal premature infant at birth. Hepatosplenomegaly, chorioretinitis, hemolytic anemia, petechiae and x-ray evidence of intracranial calcifications subsequently developed. A provisional diagnosis of toxoplasmosis was discarded when a Sabin–Feldman dye test for toxoplasmosis1 was negative. Inclusion cells were then found in the urinary sediment and gastric washings,2 and salivary-gland virus was grown in tissue culture from the patient's urine.3 The correct diagnosis of cytomegalic-inclusion disease in this patient is particularly significant because he presented what has been considered a characteristic clinical picture of toxoplasmosis.Case ReportE. E. was born on May . . .