Why the study?
Does skeletal muscle-specific deletion of LPL alter insulin sensitivity and body composition in mice?
Population
Skeletal muscle-specific LPL knockout mice and wild-type littermate control mice, aged 9-11 weeks or 8-10…
Comparison
Skeletal muscle-specific deletion of lipoprotein… vs Wild-type littermate control mice
Design
Preclinical
Follow-up
Up to 8-10 months of age
Authors
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Muscle-specific LPL deletion improves local but impairs systemic insulin sensitivity in mice; hypothesis-generating for human metabolic disease.
Does skeletal muscle-specific deletion of LPL alter insulin sensitivity and body composition in mice?
Skeletal muscle-specific deletion of LPL enhances insulin signaling in muscle but causes insulin resistance in liver and other tissues, ultimately leading to obesity and systemic insulin resistance.
Wang et al. (2008) studied this question.
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