Population
Adenovirus constructs containing variant poly(A) recognition elements (reconstructed adenovirus E1A gene)
Comparison
Insertion of MLTU poly regulation signals and… vs Wild-type MLTU (L1 to L5) utilization
Design
Preclinical
Authors
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Reveals cis control of adenovirus poly(A) switching; hypothesis-generating for viral gene regulation, needs mammalian validation.
The switch from early to late poly(A) site selection in adenovirus is regulated by a cis mechanism rather than altered processing factors.
Falck-Pedersen et al. (1989) studied this question.
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