The phosphorus distribution in blood and the calcium and phosphorus excretion during hypervitaminosis D

Kreitmar and Moll, 1928;Pfannenstiel, 1927] that the feeding of doses of irradiated ergosterol far in excess of the therapeutic dose produces well- marked metabolic disturbance, a condition which has been called hyper- vitaminosis D. This condition is characterised by an extensive deposition of calcium salts in various organs of the body and is accompanied by an increased blood-inorganic phosphate [Harris and Stewart, 1929].Hess and Lewis [1928] also observed signs of high blood-calcium and -inorganic phosphate in clinical cases of rickets, which were receiving 2x5-5 mg. of irradiated ergosterol per day.As phosphorus occurs combined in several different forms in blood, it was thought of interest to investigate whether the increase in inorganic phosphate, which in this condition can be maintained over a long period, produces any change in the blood content of acid-soluble organic phosphorus compounds.The work reported here was carried out to investigate this point.In these experiments, the technique of Kay and Robison [1924] has been employed, and the following four types of phosphorus compounds have been