Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus
Why the study?
Does type 1 diabetes mellitus increase aortic stiffness or early atherosclerosis measured by MRI in adolescents compared to healthy controls?
Population
84 adolescents, comprising 54 patients with type 1 diabetes mellitus and 30 age-matched controls.
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Supports early aortic changes in low-insulin-sensitivity T1DM adolescents; hypothesis-generating for MRI-based risk stratification.
Structured PICO
Does type 1 diabetes mellitus increase aortic stiffness or early atherosclerosis measured by MRI in adolescents compared to healthy controls?
P
Population
84 adolescents, comprising 54 patients with type 1 diabetes mellitus (T1DM) (mean age 15.4 ± 2.6 years) and 30 age-matched controls (mean age 14.8 ± 2.7 years).
C
Comparator
Age-matched healthy controls
O
Outcome
Aortic arch pulse wave velocity (PWV), strain, and distensibility of the ascending and descending thoracic aorta and measures of atherosclerosis assessed by MRIsurrogate
Adolescents with T1DM, particularly those with lower insulin sensitivity, demonstrate early signs of large vessel aortopathy as measured by MRI.
Cite This Study
McCulloch et al. (2014) studied this question.