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September 27, 2021JAMA Network OpenOpen Access

Long-term Outcomes of Transcatheter Arterial Chemoembolization Combined With Radiofrequency Ablation as an Initial Treatment for Early-Stage Hepatocellular Carcinoma

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Authors

YZYaojun ZhangSun Yat-sen University MCMin Shan Chen YCYong ChenSun Yat-sen University

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Implication

Randomized trial reveals improved overall and recurrence-free survival with combined chemoembolization and radiofrequency ablation in early liver cancer, suggesting superior long-term tumor control.

Key Points

To determine the long-term overall survival and recurrence-free survival outcomes of transcatheter arterial chemoembolization combined with radiofrequency ablation compared with radiofrequency ablation alone in early-stage hepatocellular carcinoma.
Follow-up study of a phase 3 randomized clinical trial conducted between October 2006 and June 2009 with adults with early hepatocellular carcinoma (N=189).
Participants were randomly assigned 1:1 to receive either TACE followed two weeks later by RFA (n=94) or RFA alone (n=95), with follow-up extending approximately 6 years after trial closure.
The 5-year and 7-year overall survival rates were 52.0% and 36.4% in the TACE-RFA group vs 43.2% and 19.4% in the RFA group (HR, 0.55; 95% CI, 0.39-0.78; P = .001).
The 5-year and 7-year recurrence-free survival rates were 41.4% and 34.5% in the TACE-RFA group vs 27.4% and 18.1% in the RFA group (HR, 0.66; 95% CI, 0.49-0.89; P = .007).
Subgroup analysis indicated that the survival benefit of TACE-RFA was substantially greater in patients with tumors larger than 3 cm compared with those with tumors 3 cm or smaller.

Cite This Study

Zhang et al. (2021) studied this question.

synapsesocial.com/papers/6a8645886b9f06dcfa3a61ef https://doi.org/10.1001/jamanetworkopen.2021.26992

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Implication

Randomized trial reveals improved overall and recurrence-free survival with combined chemoembolization and radiofrequency ablation in early liver cancer, suggesting superior long-term tumor control.

Long-term Outcomes of Transcatheter Arterial Chemoembolization Combined With Radiofrequency Ablation as an Initial Treatment for Early-Stage Hepatocellular Carcinoma

Discussion

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Implication

Key Points

Cite This Study

Long-term Outcomes of Transcatheter Arterial Chemoembolization Combined With Radiofrequency Ablation as an Initial Treatment for Early-Stage Hepatocellular Carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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