What question did this study set out to answer?

To evaluate the safety and clinical efficacy of narrow-band ultraviolet B phototherapy alone versus in combination with topical calcipotriol for patients with generalized vitiligo.

May 1, 2006The Journal of Dermatology

Narrow‐band ultraviolet B as monotherapy and in combination with topical calcipotriol in the treatment of vitiligo

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Authors

EAErcan ArcaGüven Hospital HTHalis Bülent TaştanMilitary Medical Academy AEAhmet Hakan ErbilGülhane Askerî Tıp Akademisi

Discussion

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Implication

Randomized trial reveals narrow-band ultraviolet B effectively repigments skin in generalized vitiligo, suggesting topical calcipotriol offers no added therapeutic benefit.

Key Points

To evaluate the safety and clinical efficacy of narrow-band ultraviolet B phototherapy alone versus in combination with topical calcipotriol for patients with generalized vitiligo.
Randomized comparative clinical study enrolling 40 patients (37 evaluated, all male) with generalized vitiligo.
Interventions comprised narrow-band ultraviolet B (311 nm) phototherapy monotherapy (n=24) versus narrow-band ultraviolet B plus 0.05% topical calcipotriol ointment applied twice daily (n=13) over a mean of 30 sessions.
In the monotherapy group (n=24), affected body surface area decreased from 27.21 ± 10.41% to 16.25 ± 8.54% (P < 0.001), achieving 41.6 ± 19.4% mean repigmentation and a 79.17% (19/24) clinical response rate.
In the combination group (n=13), affected body surface area decreased from 23.35 ± 6.5% to 13.23 ± 7.05% (P < 0.001), achieving 45.01 ± 19.15% mean repigmentation and a 76.92% (10/13) clinical response rate.
Between-group difference in repigmentation rates between monotherapy and combination therapy was not statistically significant (P > 0.05).

Cite This Study

Arca et al. (2006) studied this question.

synapsesocial.com/papers/6a8646a7da4bf993812ecfe1 https://doi.org/10.1111/j.1346-8138.2006.00079.x

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Implication

Randomized trial reveals narrow-band ultraviolet B effectively repigments skin in generalized vitiligo, suggesting topical calcipotriol offers no added therapeutic benefit.

Narrow‐band ultraviolet B as monotherapy and in combination with topical calcipotriol in the treatment of vitiligo

Discussion

Member takes

Implication

Key Points

Cite This Study

Narrow‐band ultraviolet B as monotherapy and in combination with topical calcipotriol in the treatment of vitiligo

Discussion

Member takes

Implication

Key Points

Cite This Study

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