Case series reports localized hyperpigmentation in psoriasis patients receiving combined calcipotriol and bath PUVA photochemotherapy, highlighting an adverse pigmentary reaction.
The vitamin D3 analogue calcipotriol (calcipotriene) is an effective topical treatment for psoriasis. In combination with other antipsoriatic agents, such as ultraviolet radiation, calcipotriol is reported to improve the overall efficacy of the treatment. Here we describe two patients treated with a combination treatment of calcipotriol and bath psoralens and ultraviolet A who developed hyperpigmentation at the lesional sites where calcipotriol ointment was applied.
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Gläser et al. (1998) studied this question.
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