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The influence of local application of haemostasis, peripheral blood, autologous bone marrow and Fibrin Adhesive System (FAS) on bone formation rate in osseointegrated titanium implants, were studied. The Bone Harvest Chamber (BHC) implant utilized has a penetrating canal, enabling osseous ingrowth in situ. After integration of one implant into the cortex of the proximal tibial metaphysis of a rabbit, newly formed bone was harvested in repetitive three-week periods. The specimens were quantified by microradiography-videodensitometry and subjected to further histological examination. The amounts of bone formed in two equally treated chambers in the same animal were compared. It was concluded, that the conditions for bone regeneration in an osseointegrated titanium implant are excellent, minimally influenced by locally applied haemostasis, peripheral blood and autologous bone marrow. FAS pretreatment on the other hand was found to impair bone formation.
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Kälebo et al. (1988) studied this question.
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