What question did this study set out to answer?

To compare the diagnostic accuracy of the T-cell-based T-SPOT.TB assay against the tuberculin skin test (TST) for identifying latent tuberculosis infection in immunocompromised patients.

March 15, 2006European Respiratory JournalOpen Access

Use of a T-cell-based test for detection of tuberculosis infection among immunocompromised patients: Table 1—

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Authors

FPFederica PianaSchool of the Art Institute of Chicago LCLuigi Ruffo CodecasaAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda PCP. CavallerioUniversity of Trento

Discussion

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Implication

Diagnostic study demonstrates superior detection of latent tuberculosis by T-SPOT.TB over skin testing in immunocompromised patients, indicating preserved sensitivity despite immunosuppression.

Key Points

To compare the diagnostic accuracy of the T-cell-based T-SPOT.TB assay against the tuberculin skin test (TST) for identifying latent tuberculosis infection in immunocompromised patients.
Evaluated 138 immunosuppressed haematology patients who experienced nosocomial exposure to a smear-positive tuberculosis index case.
Assessed diagnostic positivity, concordance, and indeterminate test rates across different degrees of immunosuppression.
Overall positive test rates were 44.2% for T-SPOT.TB compared to 17.4% for TST, with a concordance rate of 67.8%.
TST positivity decreased from 25.9% to 14.5% with increasing levels of immunosuppression, whereas T-SPOT.TB positivity remained virtually unchanged at 44.6% and 44.3%.
The T-SPOT.TB assay had an overall indeterminate rate of 4.3%, which did not vary according to the level of immunosuppression.

Cite This Study

Piana et al. (2006) studied this question.

synapsesocial.com/papers/6a864816da4bf993812ed154 https://doi.org/10.1183/09031936.06.00110205

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Implication

Diagnostic study demonstrates superior detection of latent tuberculosis by T-SPOT.TB over skin testing in immunocompromised patients, indicating preserved sensitivity despite immunosuppression.

Use of a T-cell-based test for detection of tuberculosis infection among immunocompromised patients: Table 1—

Discussion

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Implication

Key Points

Cite This Study

Use of a T-cell-based test for detection of tuberculosis infection among immunocompromised patients: Table 1—

Discussion

Member takes

Implication

Key Points

Cite This Study

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