Antihypertensive therapy responsiveness and adverse outcomes in preeclampsia: insights into molecular mechanisms underlying cardiovascular and renal complications

Marcelo R. Luizon; Daniela A. Pereira; Izabela Mamede; Carla S. Ceron; Ricardo de Carvalho Cavalli; Ana C. Palei; Valéria C. Sandrim

doi:10.3389/fphar.2023.1281382

November 22, 2023Frontiers in PharmacologyOpen Access

Antihypertensive therapy responsiveness and adverse outcomes in preeclampsia: insights into molecular mechanisms underlying cardiovascular and renal complications

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Key Points

Investigate the molecular mechanisms linking antihypertensive therapy responsiveness to adverse cardiovascular and renal outcomes in preeclampsia.
Evaluated vascular signaling pathways, endothelial dysfunction markers, and genetic polymorphisms associated with drug responsiveness.
Assessed molecular roles of matrix metalloproteinases (MMP-2, TIMP-3), nitric oxide bioavailability, and NAMPT in organ injury.
Identified MMP-2, TIMP-3, and NAMPT signaling variations as key determinants of vascular remodeling and antihypertensive drug efficacy.
Demonstrated that compromised nitric oxide pathways and severe endothelial dysfunction correlate with heightened risks for renal and cardiovascular damage.

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Implication

Review demonstrates molecular drivers of antihypertensive responsiveness in preeclampsia, highlighting mechanisms underlying cardiovascular and renal complications.

Abstract

antihypertensive agents, endothelial dysfunction, genetic polymorphisms, matrix metalloproteinase (MMP)-2, nicotinamide phosphoribosyltransferase (NAMPT), nitric oxide, preeclampsia, tissue inhibitor of metalloproteinase (TIMP)-3

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Luizon et al. (2023) studied this question.

synapsesocial.com/papers/6a8648dae93d6dba1c639477 https://doi.org/10.3389/fphar.2023.1281382

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Antihypertensive therapy responsiveness and adverse outcomes in preeclampsia: insights into molecular mechanisms underlying cardiovascular and renal complications

Key Points

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Implication

Abstract

Discussion

Cite This Study

Antihypertensive therapy responsiveness and adverse outcomes in preeclampsia: insights into molecular mechanisms underlying cardiovascular and renal complications

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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