Key result
Antihypertensive-resistant pre-eclampsia plasma evokes distinct HUVEC gene expression profiles compared to responsive patient plasma.
Why the study?
Does plasma from pre-eclampsia patients nonresponsive to antihypertensive therapy evoke different endothelial gene expression in HUVEC compared to plasma from responsive patients?
Does plasma from pre-eclampsia patients nonresponsive to antihypertensive therapy evoke different endothelial gene expression in HUVEC compared to plasma from responsive patients?
Plasma from pre-eclampsia patients nonresponsive to antihypertensive therapy evokes different endothelial gene expression profiles in HUVEC compared to responsive patients, suggesting potential pharmacogenomic mechanisms.
Answers are grounded in this paper and cite their sources.
No immediate change to pre-eclampsia antihypertensive selection; hypothesis-generating for endothelial gene networks as response predictors.
AIM: Over 40% of patients with pre-eclampsia are nonresponsive to antihypertensive therapy, but the underlying mechanisms are unknown. We examined the effects of plasma from nonresponsive and responsive patients on endothelial gene expression. PATIENTS & METHODS: PCR array was performed in human umbilical vein endothelial cells (HUVEC) incubated with plasma from nonresponsive (n = 4) and responsive (n = 4) patients. Gene networks and interactions with antihypertensive drugs used in pre-eclampsia were identified by Ingenuity Pathway Analysis. RESULTS: Nifedipine and hydralazine act by upregulate or downregulate genes found to be downregulated or upregulated in HUVEC incubated with plasma from nonresponsive patients. CONCLUSION: Our novel findings suggest that plasma from nonresponsive and responsive patients evoke different responses in HUVEC, and might advance the pharmacogenomics research in pre-eclampsia.
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Luizon et al. (2016) studied Pre-eclampsia (n=8). Plasma from nonresponsive patients vs. Plasma from responsive patients was evaluated on Endothelial gene expression in human umbilical vein endothelial cells (HUVEC). Plasma from pre-eclampsia patients nonresponsive to antihypertensive therapy evoked different gene expression responses in HUVEC compared to plasma from responsive patients.
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