Why the study?
Does enhanced inactivated poliovirus vaccine (eIPV) elicit a neutralizing antibody response in HIV-infected patients?
Population
20 homosexual men (17 HIV-infected and 3 HIV-seronegative)
Comparison
Enhanced inactivated poliovirus vaccine (eIPV) vs HIV-seronegative men and pre-vaccination baseline
Design
Cohort
Authors
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Supports caution with eIPV in advanced HIV; leaves open optimal polio vaccination approaches in immunocompromised patients.
Does enhanced inactivated poliovirus vaccine (eIPV) elicit a neutralizing antibody response in HIV-infected patients?
The response to eIPV immunization in HIV-infected patients correlates with the number of circulating T4 cells, with failure to respond in those with low T4 counts.
Vardinon et al. (1990) studied this question.
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