The Level of Expression of Ki-67 in Invasive Cervical Cancers and Cervical Intraepithelial Neoplasia in Ghanaian Women

Increased cellular proliferation and cell cycle abnormalities have been associated with development of cervical cancer and cervical intraepithelial neoplasia in women. Criteria for grading of these lesions by pathologist based on digression in growth and degree of invasiveness among other abnormalities have been affected by inter and intra-observer differences resulting in poor reproducibility. Ki-67, a proliferative marker is useful in grading of cervical cancer and cervical intraepithelial neoplasia by giving uniform and reliable outcome independent of inter and intra-observer differences.