Population
Anesthetized rabbits prepared for renal micropuncture and renal sympathetic nerve activity (RSNA) recording
Comparison
ANG II clamp during 14% O2 exposure vs Vehicle during 14% O2 exposure
Design
Preclinical
Authors
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May support RAS-independent renal nerve control of postglomerular resistance in hypoxia; hypothesis-generating, translation to humans needed.
The action of renal nerves on the postglomerular vasculature is independent of the renin-angiotensin system, supporting the hypothesis that increases in RSNA can selectively control pre- and postglomerular vascular resistance.
Denton et al. (2004) studied this question.
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