Population
Rat proximal tubule, renal cortex, and LLC-PK1 cells (euthyroid, hypothyroid, and hyperthyroid rats)
Comparison
Thyroid hormone treatment vs Euthyroid and hypothyroid states
Design
Preclinical
Authors
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Thyroid hormone effects on rat renal NHE mRNA without protein change; hypothesis-generating for human thyroid-renal sodium handling.
Thyroid hormone treatment increases NHE3 mRNA but not protein levels in the rat renal cortex, suggesting parallel changes in synthesis and turnover.
Azuma et al. (1996) studied this question.
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