Why the study?
Do sympathomimetic amines lower the ventricular fibrillation threshold in the isolated rabbit heart?
Population
Isolated heart of the rabbit perfused via the aorta with McEwen's solution at 37 degrees C
Design
Preclinical
Authors
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Does not support clinical changes in arrhythmia management; leaves open translation of beta-adrenergic VFT effects to intact models or humans.
Do sympathomimetic amines lower the ventricular fibrillation threshold in the isolated rabbit heart?
Adrenaline, noradrenaline, and isoprenaline lower the ventricular fibrillation threshold in isolated rabbit hearts via a direct action on beta-adrenoceptors.
Maurice F. Murnaghan (1975) studied this question.
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