Why the study?
What are the side effects associated with long-term amiodarone therapy?
What are the side effects associated with long-term amiodarone therapy?
Long-term amiodarone therapy is associated with significant dose-dependent and metabolism-related side effects affecting multiple organ systems.
Mandates vigilant multiorgan monitoring with long-term amiodarone; leaves open true incidence and risk mitigation.
Although amiodarone is an effective antiarrhythmic agent, long-term therapy may be associ- ated with unwanted effects.We report our experience in 140 patients treated over 5 years.Important effects were seen particularly in the thyroid gland, liver, lung and skin.Some of these effects are dose-dependent and others may be related to the chemical structure and metabolism of amiodarone.Corneal microdeposits were always found when sought, but did not cause impairment of visual acuity.
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Harris et al. (1983) studied this question.
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