Key result
Amiodarone exposure in one patient (N=1) led to a combination of serious toxicities that were successfully treated and resulted in a good clinical outcome.
Case Report (n=1)
Amiodarone can cause severe, multi-system toxicities that require prompt recognition and treatment or discontinuation to prevent fatal outcomes.
Prompt recognition of amiodarone multi-toxicity enables reversal; leaves open need for prospective incidence and management data.
Amiodarone is an iodinated benzofuran derivative class III antiarrhythmic that is highly effective in suppressing ventricular and supraventricular arrhythmias. It is also associated with an imposing side effect profile, which often limits its use. Numerous adverse effects have been documented including skin discolouration, photosensitivity, hepatitis, thyroid dysfunction, corneal deposits, pulmonary fibrosis, bone marrow suppression and drug interactions. These side effects are thought to be correlated with the total cumulative dose of amiodarone, but idiopathic reactions have been reported. The majority of adverse reactions resolve with discontinuation of the drug; however, rapid progression may occur, which may be fatal. The present report documents a patient who had a combination of serious amiodarone toxicities that, once recognized, were treated and eventually resulted in a good outcome.
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Burns et al. (2000) conducted a case report in Amiodarone toxicity (n=1). Amiodarone was evaluated. Amiodarone exposure in one patient (N=1) led to a combination of serious toxicities that were successfully treated and resulted in a good clinical outcome.
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