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Does the anti-CCP2 test provide high specificity and sensitivity for the early diagnosis of rheumatoid arthritis?
Does the anti-CCP2 test provide high specificity and sensitivity for the early diagnosis of rheumatoid arthritis?
The anti-CCP2 test is a highly specific and sensitive serological marker for the early diagnosis and prognostic evaluation of rheumatoid arthritis.
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Anti-CCP2 testing may refine early RA diagnosis; leaves open prospective studies to confirm clinical impact over rheumatoid factor.
The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95-99%) and has sensitivity comparable to that of the rheumatoid factor (70-75%). The antibodies can be detected very early in the disease and can be used as an indicator for the progression and prognosis of RA. In this review, these interesting properties and some future possibilities of this diagnostic test are discussed.
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Venrooij et al. (2007) studied this question.
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