Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1995Arteriosclerosis Thrombosis and Vascular Biology

Coronary Heart Disease Risk Factors in Women With Polycystic Ovary Syndrome

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do women with polycystic ovary syndrome have an increased burden of cardiovascular disease risk factors compared to matched controls?

Population

412 women. PCOS defined as history of chronic anovulation with clinical evidence of androgen excess or total…

Design

Case-control

Authors

ETEvelyn O. TalbottUniversity of PittsburghDGDavid S. GuzickBrown UniversityACAnnette ClericiUniversity of Pittsburgh

Discussion

Loading...

Member takes

Implication

May support earlier CVD risk monitoring in PCOS; hypothesis-generating and requires prospective outcome studies.

Structured PICO

Do women with polycystic ovary syndrome have an increased burden of cardiovascular disease risk factors compared to matched controls?

P
Population
412 women (206 with polycystic ovary syndrome [PCOS] and 206 matched controls). PCOS defined as history of chronic anovulation with clinical evidence of androgen excess or total testosterone >2 nm/L or LH/FSH ratio >2. Mean age 35.9±7.4 years for cases and 37.2±7.8 years for controls.
C
Comparator
Control subjects matched by age±5 years, race, and neighborhood
O
Outcome
Cardiovascular disease risk factors (body mass index, insulin, triglycerides, HDL, LDL, total cholesterol, waist/hip ratio, systolic blood pressure)surrogate

Women with PCOS have a significantly worse cardiovascular risk factor profile, including dyslipidemia and insulin resistance, independent of age and BMI, warranting early monitoring and intervention.

Cite This Study

Talbott et al. (1995) studied this question.

synapsesocial.com/papers/6a86555acdf6ddc25c832ecchttps://doi.org/10.1161/01.atv.15.7.821

Topics

Women and heart disease
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure1982 · 764 citations
  2. 2Role of Insulin Resistance in Human Disease1988 · 12,161 citations
  3. 3Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,635 citations
  4. 4The Polycystic Ovary Syndrome: Pathogenesis and Treatment1989 · 164 citations
  5. 5Evidence for a single gene effect causing polycystic ovaries and male pattern baldness1993 · 288 citations