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July 1, 2008Cancer Research

Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer

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Population

Ovarian cancer cell lines (n=23) and primary ovarian cancer tissues (n=100 cases)

Comparison

Restoration of ANGPTL2 expression, treatment… vs Control/untreated ovarian cancer cells

Design

Preclinical

Authors

RKRyoko KikuchiAsahikawa Medical College HospitalHTHitoshi TsudaChiba UniversityKKKen‐ichi KozakiOkayama University

Discussion

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Implication

No change to ovarian cancer practice warranted; hypothesis-generating for ANGPTL2 as epigenetic tumor suppressor.

Structured PICO

P
Population
Ovarian cancer cell lines (n=23) and primary ovarian cancer tissues (n=100 cases)
I
Intervention
Restoration of ANGPTL2 expression, treatment with conditioned medium containing ANGPTL2, knockdown of endogenous ANGPTL2, or 5-aza 2'-deoxycytidine treatment
C
Comparator
Control/untreated ovarian cancer cells
O
Outcome
ANGPTL2 expression, methylation status, cell growth, and patient survivalsurrogate

Epigenetic silencing of ANGPTL2 by hypermethylation leads to loss of its putative tumor suppressor function in ovarian cancer.

Cite This Study

Kikuchi et al. (2008) studied this question.

synapsesocial.com/papers/6a86556dbc4cc88ab58334c5https://doi.org/10.1158/0008-5472.can-08-0062
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Also Consider

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  1. 1Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness2006 · 258 citations
  2. 2Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer2007 · 76 citations
  3. 3Comparative genomic hybridization (CGH)‐arrays pave the way for identification of novel cancer‐related genes2004 · 122 citations
  4. 4A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types1994 · 2,798 citations