Why the study?
There is no consensus on how to report cytoplasmic and mitotic ANA patterns as negative or positive.
What are the clinical characteristics and diagnostic associations of patients with cytoplasmic or mitotic staining patterns on ANA testing?
What are the clinical characteristics and diagnostic associations of patients with cytoplasmic or mitotic staining patterns on ANA testing?
Cytoplasmic or mitotic patterns in ANA testing are rare (2.07%) and do not show statistically significant associations with specific rheumatological diagnoses in ANA-negative patients, suggesting they should be reported as negative with descriptive notes.
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Kaşifoğlu et al. (2022) studied this question.
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