Why the study?
CPB can trigger organ damage, including kidney injury, through cytokine release, but the impact of chronic ACE-I treatment on this inflammatory response and postoperative renal function was unclear.
Does long-term ACE-inhibitor use alter the inflammatory response and affect renal function in patients undergoing major cardiac surgery with cardiopulmonary bypass?
Comparison
Long-term (> 6 mo.) ACE-I use vs no ACE-I use
Design
Observational, prospective study
Follow-up
10 days
Authors
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Chronic ACE-I use may modulate select post-CPB cytokines without altering AKI incidence or GFR recovery; leaves open any clinical renal benefit in larger trials.
Does long-term ACE-inhibitor use alter the inflammatory response and affect renal function in patients undergoing major cardiac surgery with cardiopulmonary bypass?
Long-term ACE-inhibitor use prior to cardiac surgery with cardiopulmonary bypass alters the postoperative inflammatory response but does not significantly affect perioperative renal outcomes such as acute kidney injury.
Presta et al. (2021) studied this question.