The Treatment of Systemic Blastomycosis With Stilbamidine

Article1 July 1952THE TREATMENT OF SYSTEMIC BLASTOMYCOSIS WITH STILBAMIDINEEMANUEL B. SCHOENBACH, M.D., F.A.C.P., JOSEPH M. MILLER, M.D., PERRIN H. LONG, M.D.EMANUEL B. SCHOENBACH, M.D., F.A.C.P.Search for more papers by this author, JOSEPH M. MILLER, M.D.Search for more papers by this author, PERRIN H. LONG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-1-31 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough infrequent in occurrence, blastomycotic infections are important because of the morbidity and mortality associated with the systemic form of the disease. Treatment has been varied and generally ineffectual. The observation of Elson7 that certain of the diamidines exerted a fungistatic effect on Blastomyces dermatitidis led to the treatment of a patient suffering from systemic blastomycosis with two of the diamidines.Blastomycosis is seen in both the white and Negro races, usually in the third through the fifth decades of life and in the lower economic strata. The incidence is much higher in males. Farmers are more frequently affected than...Bibliography1. AraiSnapper HI: The influence of stilbamidine upon kidney function, liver and peripheral blood in multiple myeloma. Neurologic sequelae of stilbamidine therapy, New York State J. Med. 47: 1867-1874 (Sept.) 1947. MedlineGoogle Scholar2. BarberSlackWien HJRR: Increase in toxicity of stilbamidine solution on exposure to light, Nature, London 151: 107-108 (Jan. 23) 1943. CrossrefGoogle Scholar3. Bowesman C: A short report on the use of 4:4′ diamidino stilbene in the treatment of human sleeping sickness, Ann. Trop. Med. 34: 217-222 (Dec.) 1940. CrossrefGoogle Scholar4. CollardHargreaves PJWH: Neuropathy after stilbamidine treatment of kala-azar, Lancet 2: 686-688 (Nov. 8) 1947. CrossrefMedlineGoogle Scholar5. CollardNevin PS: Affection of the trigeminal nerve nucleus and central grey matter of the spinal cord following the administration of stilbamidine, Proc. Roy. Soc. Med. 40: 87-88 (Nov. 7) 1946. CrossrefMedlineGoogle Scholar6. Devine J: Studies in chemotherapy. XXIV. Changes in the blood produced by administration of 4:4′ diamidino stilbene, Ann. Trop. Med. 34: 67-71 (April) 1940. CrossrefGoogle Scholar7. Elson WO: The antibacterial and fungistatic properties of propamidine, J. Infect. Dis. 76: 193-197 (May-June) 1945. CrossrefGoogle Scholar8. FriedmanSignorelli LLJJ: Blastomycosis: a review of the literature and a report of a case involving the meninges, Ann. Int. Med. 24: 385-400 (March) 1946. LinkGoogle Scholar9. Fulton JD: Studies in chemotherapy. XXIII. Toxicity and therapeutic action of certain aromatic diamidines after exposure to light, Ann. Trop. Med. 37: 48-59 (April) 1943. CrossrefGoogle Scholar10. FultonGoodwin JDTW: Studies in the estimation, absorption and precipitation of stilbamidine, J. Pharmacol. and Exper. Therap. 84: 34-45 (May) 1945. Google Scholar11. FultonYorke JDW: Studies in chemotherapy. XXXI. The increased toxicity of old solutions of stilbamidine, Ann. Trop. Med. 36: 134-136 (Sept.) 1942. CrossrefGoogle Scholar12. HaedickeGreenspan TAEM: Massive stilbamidine therapy of multiple myeloma. Report of a case, Am. J. Clin. Path. 19: 634-638 (July) 1949. CrossrefMedlineGoogle Scholar13. Henry AJ: Instability of stilbamidine in aqueous solution, Nature, London 152: 690-692 (Dec. 11) 1943. CrossrefGoogle Scholar14. Henry AJ: The bromination of 4:4′-diamidino-α-γ-diphenoxypropane and of 4:4′ diamidino-stilbene, J. Chem. Soc. London 2: 870-873, 1945. Google Scholar15. Henry AJ: The photochemical instability of cis and trans 4:4′ diamidino-stilbene, J. Chem. Soc. London 2: 1156-1164, 1947. Google Scholar16. HenryGrindley AJRN: Fluorescence and absorption of stilbamidine and its estimation in biological fluids, Ann. Trop. Med. 36: 102-112 (Sept.) 1942. CrossrefGoogle Scholar17. JonesMartin RRDS: Blastomycosis of bone. A review of 63 collected cases of which 6 recovered, Surgery 10: 931-938 (Dec.) 1941. Google Scholar18. KirkHenry RAJ: Observations on the toxicity of stilbamidine, Ann. Trop. Med. 38: 99-118 (Sept.) 1944. CrossrefGoogle Scholar19. LittmanWickerWarren MLEHAS: Systemic North American blastomycosis. Report of a case with cultural studies of the etiologic agent and observations on the effect of streptomycin and penicillin in vitro, Am. J. Path. 24: 339-365 (March) 1948. MedlineGoogle Scholar20. MartinJones DSRR: Systemic blastomycosis. Report of a case with unusual immunologic findings, well two years after onset, Surgery 10: 939-946 (Dec.) 1941. Google Scholar21. MartinSmith DSDT: Blastomycosis (American blastomycosis, Gilchrist's disease). I. A review of the literature, Am. Rev. Tuberc. 39: 275-299 (March) 1939. Google Scholar22. MartinSmith DSDT: (American blastomycosis, Gilchrist's disease). II. A report of thirteen new cases, Am. Rev. Tuberc. 39: 488-515 (April) 1939. Google Scholar23. NapierSen Gupta LEPC: A peculiar neurological sequel to administration of 4:4′ diamidino-diphenyl ethylene (M and B 744), Indian M. Gaz. 77: 71-74 (Feb.), 1942. MedlineGoogle Scholar24. NapierSen GuptaSen LEPCGN: The treatment of kala-azar by diamidino stilbene: analysis of 101 cases, Indian M. Gaz. 77: 321-388 (May) 1942. MedlineGoogle Scholar25. OastlerFidler EGHK: Cerebral lesions produced in healthy dogs by the intravenous injection of 4:4′ diamidino stilbene, Trans. Roy. Soc. Trop. Med. and Hyg. 39: 533-538 (June) 1946. CrossrefMedlineGoogle Scholar26. SchoenbachGreenspan EBEM: The pharmacology, mode of action and therapeutic potentialities of stilbamidine, pentamidine, propamidine and other aromatic diamidines: a review, Medicine 27: 327-377 (Sept.) 1948. CrossrefMedlineGoogle Scholar27. SchoenbachMillerGinsbergLong EBJMMPH: Systemic blastomycosis treated with stilbamidine, a preliminary report, J. A. M. A. 146: 1317-1318 (Aug.) 1951. CrossrefMedlineGoogle Scholar28. SeagerCastelnuovo LDG: Toxicity of "stilbamidine." A study of the effects of chronic intoxication, Arch. Path. 44: 287-296 (Sept.) 1944. Google Scholar29. SeagerCastelnuovo LDG: The acute and chronic toxicity of stilbamidine, Federation Proc. 5: 201, 1946. MedlineGoogle Scholar30. SelbieMcIntosh FRJ: The action of chemotherapeutic drugs (including proflavine) and excipients on healthy tissue, J. Path. and Bact. 55: 477-481 (Oct.) 1943. CrossrefGoogle Scholar31. Sen Gupta PC: Observations on the neuropathic sequel of diamidino-stilbene therapy in kala-azar, Indian M. Gaz. 78: 537-543 (Nov.) 1943. MedlineGoogle Scholar32. Snapper I: Referred to by Schoenbach, E. B., and Greenspan, E. M.: The pharmacology, mode of action and therapeutic potentialities of stilbamidine, pentamidine, propamidine and other aromatic diamidines: a review, Medicine 27: 325-377 (August) 1948. Google Scholar33. SnapperLiebenGreenspanSchneid IFEB: Determination of stilbamidine and 2-hydroxy-stilbamidine deposited in parenchymatous organs and tumors, Cancer 4: 1246-1249 (Nov.) 1951. CrossrefMedlineGoogle Scholar34. Wien R: The pharmacological actions of certain aromatic diamidines possessing trypanocidal activity, Ann. Trop. Med. 37: 1-18 (April) 1943. CrossrefGoogle Scholar35. Wien R: Excretion of stilbamidine, Tr. Roy. Soc. Trop. Med. and Hyg. 39: 455-458 (April) 1946. CrossrefMedlineGoogle Scholar36. WienFreemanScotcher RWNM: The metabolic effects produced by certain aromatic diamidines, Ann. Trop. Med. 37: 19-33 (April) 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 19, 1952.Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.From the Department of Medicine, State University of New York, College of Medicine at New York City, The Maimonides Hospital of Brooklyn, New York, and the Surgical Services, Veterans Administration, Fort Howard, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlastomycosis of the Esophagus Presenting With Gastrointestinal BleedingBlastomycosis of the EsophagusDie Nordamerikanische BlastomykoseGenitourinary Blastomycosis: A Report of Three CasesAn isolated blastomycetoma of the posterior cranial fossa treated successfully with surgery and amphotericin BDie AntimykoticaCryptococcosis (Torulosis)THE TOXICITY OF 2-HYDROXYSTILBAMIDINE: PROBABLE FATAL TOXIC REACTION DURING TREATMENT OF BLASTOMYCOSIS*J. WILLIAM OBERMAN, M.D., ENID F. GILBERT, M.D.Genitourinary Blastomycosis: Case Report and Review of LiteratureDie Pilzerkrankungen der LungeExperiences with the Therapy of Sixty Cases of Deep Mycotic InfectionsA case of coexistent non-meningitic cryptococcosis and Boeck's sarcoidNorth American blastomycosisAminostilbamidine—A Fungistatic AgentRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Blastomycosis Treated by Stilbamidine with RelapseTherapy for Pulmonary and Systemic Fungus DiseasesNorth American Blastomycosis and Bronchial CarcinomaStilbamidine Isethionate Therapy of Tic DouloureuxTHE RESULTS OF 2-HYDROXYSTILBAMIDINE THERAPY IN DISSEMINATED COCCIDIOIDOMYCOSIS*I. SNAPPER, M.D., F.A.C.P., LYLE A. BAKER, M.D., F.A.C.P., BERNARD D. EDIDIN, M.D., DANIEL S. KUSHNER, M.D.The Treatment of Pulmonary BlastomycosisThe mycotic infections of the bronchial-pulmonary tractPULMONARY BLASTOMYCOSISNORTH AMERICAN BLASTOMYCOSIS: CLINICAL FORMS OF THE DISEASE AND TREATMENT WITH STILBAMIDINE AND 2-HYDROXYSTILBAMIDINE*W. D. SUTLIFF, M.D., J. WARREN KYLE, M.D., JOHN L. HOBSON, M.D.Effect of Stilbamidine Therapy on Experimental Blastomyces Dermatitidis Infections in Mice1Blastomycosis of the Prostate with Miliary Dissemination Treated by StilbamidinePULMONARY BLASTOMYCOSISTHE EFFECT OF STILBAMIDINE AND PROPAMIDINE ON THE OXIDATIVE METABOLISM OF BLASTOMYCES DERMATITIDISThe treatment of North American blastomycosis with 2-hydroxystilbamidineMycologyIn Vitro Fungistatic Activity of Stilbamidine, Propamidine, Pentamidine and Diethylstilbestrol1A LONG-TERM EVALUATION OF AUREOMYCIN IN THE TREATMENT OF ACTINOMYCOSIS*LEON V. MCVAY JR., M.D., DOUGLAS H. SPRUNT, M.D., F.A.C.P.Failure of Stilbamidine to Arrest Experimental Blastomycosis in MiceLichen Myxedematosus (Differentiation from Cutaneous Myxedemas or Mucoid States)THE RELIEF OF TIC DOULOUREUX WITH STILBAMIDINE*GEORGE W. SMITH, M. D., JOSEPH M. MILLER, M.D. 1 July 1952Volume 37, Issue 1Page: 31-47KeywordsArmed forcesBlastomycesBlastomycosisHospital medicineInfectious diseasesMorbidityMortalityPatientsRacial and ethnic issuesSystemic diseases ePublished: 1 December 2008 Issue Published: 1 July 1952 PDF downloadLoading ...